Are reentrant atrial tachycardias sensitive to adenosine administration?

Abstract Funding Acknowledgements Type of funding sources: None. Background Adenosine (ADN) infusion may terminate focal atrial tachycardia (AT). However, the effect ADN on reentrant (RAT) is unclear and based case reports small series. These latter included mostly patients with cavotricuspid isthmus-dependent flutter provided conflicting results, RAT termination found when it involved septal or tricuspid/mitral valve regions. Purpose The aim this study was to test response (termination, transient suppression no effect) RATs evaluate differences according AT location. Methods prospectively studied at time catheter ablation in consecutive AT. Only were included. This mechanism established by activation entrainment mapping confirmed ablation. A 10 mg adenosine 5'-triphosphate (ATP) bolus administered all effects cycle length termination. Additional ATP 20 30 if AV block for least 2 secs obtained former ones. Results 58 (67, ±13 years old; 11 female) 79 38 right sided (34 isthmus-depend flutters, 1 lateral atrium reentry, upper loop superior vena cava reentry around coronary sinus) 41 left (21 perimitral 16 peripulmonary vein 4 a free wall reentry). No terminated had >20 ms prolongation following administration. There transformation into other mechanisms fibrillation any case. complications. Conclusion are insensitive infusion, neither nor prolongation.